"Depending on the task, whether it is something as gentle as picking a flower or as hard as hitting a baseball with great force, our brain first needs to determine how much force is needed and then execute it correctly. "Each day we engage in a multitude of motor tasks which require intricate coordination between different brain regions," said Sih-Rong Wu, a graduate student in the Zoghbi lab and first author of the study.
Zoghbi, also a distinguished service professor at Baylor College of Medicine and founding director of the Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas Children's Hospital. The study was led by Howard Hughes Medical Institute investigator, Dr. DOI: 10.1126/sciadv.adg1671Ī recent study published in Science Advances by researchers at Baylor College of Medicine and Texas Children's Hospital has discovered six distinct neuronal lineages in the pons region of the brainstem and revealed new insights into their differential vulnerability to the partial loss of Atoh1, a gene crucial for the development of pontine neurons.
The dashed lines outline the area of the PN. (D) Whole-mount X-gal staining on mouse hindbrain at P21 (ventral view). Atoh1 Cre/+ knock-in mouse was crossed with mouse carrying either wild-type or hypomorphic Atoh1 (Atoh1 S193A) and a Cre-dependent lacZ allele. (C) Strategy to label the Atoh1-lineage neurons.
The arrows and arrowheads denote the neurons at the PN and in the AES, respectively. (B) Whole-mount X-galactosidase (X-gal) staining on mouse hindbrain at P0 (ventral view). PN neurons migrate from cRL to ventral pons through AES during E12.5 to E18.5. (A) Schematic representation of the PN development in mice. Phospho-mutation of Atoh1 at serine-193 leads to PN hypoplasia in mice.
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