However, many of these deficits may not become apparent until school age, when higher-level organizational skills are required. A distinct pattern of mild cognitive and behavioral impairment associated with problems with reasoning, learning, memory, executive function, inattention, and impulsive behavior, language, and social skills has emereged ( Bellinger et al., 2015 Bellinger et al., 2011 Cassidy, White, DeMaso, Newburger & Bellinger, 2015 von Rhein et al., 2015 Murphy et al., 2015).
Mechanisms contributing to cognitive deficits in CHD are complex and multifactorial including hypoxic/ischemic injury triggered by the CHD condition, hypoperfusion during cardiac surgery, and a wide range of genetic, prenatal, and other pre- and postoperative risk factors ( Gaynor et al., 2015 Dominguez, Wernovsky, & Gaynor, 2007 Ballweg, Wernovsky, & Gaynor, 2007). The prevalence of cognitive deficits has been estimated in up to 50% of survivors with complex CHD ( Markowitz, Ichord, Wernosky, Gaynor, & Nicholson, 2007 Wernovsky, 2006).
Cognitive deficits are the most common, and potentially the most harmful, sequelae of adolescents and young adults with congenital heart disease (CHD) who have undergone surgical palliation.
0 kommentar(er)
